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ets2  (Santa Cruz Biotechnology)


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    Structured Review

    Santa Cruz Biotechnology ets2
    a Consensus <t>ETS2</t> binding motif from the JASPAR database of transcription factor DNA-binding preferences (Matrix ID: MA1484.1) and alignment of the variant site in several mammals. The risk allele (C) is the reference allele but has a lower frequency than the non-risk allele (T) in most populations. The risk allele improves the match to the ETS2 binding site which remains partial. b , c Percent input identified by ChIP-qPCR for anti-ETS2 and anti-H3K27Ac respectively in iOE cells heterozygous for rs661849 using primers specific to the IRF6 −22 kb enhancer site or, as a negative control, to a region 103.7 kb upstream IRF6 transcription start site lacking ATAC-Seq and H3K27Ac ChIP-Seq signals in HIOEC or NHEK. Error bars refer to three ChIP replicates and expressed as mean ± SD. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. NS non-significant. d Sequencing of anti-ETS2 and anti-H3K27Ac ChIP-PCR product of cells heterozygous for rs661849 using the indicated antibody. e Scattered dot plot of relative luciferase activity of the IRF6 −22 kb reporter construct (longest version) harboring the risk allele of rs661849 in control versus ETS2 -depleted primary neonatal keratinocytes (HEKn). Data are represented as mean ± SD from three independent experiments. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. f Scattered dot plot of relative levels of IRF6 mRNA in control versus ETS2 -depleted HEKn assessed by qRT-PCR. Expression levels of IRF6 are normalized against ACTB . Data are represented as mean ± SD from three replicates. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. g Model showing binding of ETS2 to the IRF6 −22 kb enhancer, which is favored by the risk allele and which reduces IRF6 expression. Source data are provided as a Source Data file.
    Ets2, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ets2/product/Santa Cruz Biotechnology
    Average 93 stars, based on 6 article reviews
    ets2 - by Bioz Stars, 2026-05
    93/100 stars

    Images

    1) Product Images from "Identification of functional non-coding variants associated with orofacial cleft"

    Article Title: Identification of functional non-coding variants associated with orofacial cleft

    Journal: Nature Communications

    doi: 10.1038/s41467-025-61734-w

    a Consensus ETS2 binding motif from the JASPAR database of transcription factor DNA-binding preferences (Matrix ID: MA1484.1) and alignment of the variant site in several mammals. The risk allele (C) is the reference allele but has a lower frequency than the non-risk allele (T) in most populations. The risk allele improves the match to the ETS2 binding site which remains partial. b , c Percent input identified by ChIP-qPCR for anti-ETS2 and anti-H3K27Ac respectively in iOE cells heterozygous for rs661849 using primers specific to the IRF6 −22 kb enhancer site or, as a negative control, to a region 103.7 kb upstream IRF6 transcription start site lacking ATAC-Seq and H3K27Ac ChIP-Seq signals in HIOEC or NHEK. Error bars refer to three ChIP replicates and expressed as mean ± SD. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. NS non-significant. d Sequencing of anti-ETS2 and anti-H3K27Ac ChIP-PCR product of cells heterozygous for rs661849 using the indicated antibody. e Scattered dot plot of relative luciferase activity of the IRF6 −22 kb reporter construct (longest version) harboring the risk allele of rs661849 in control versus ETS2 -depleted primary neonatal keratinocytes (HEKn). Data are represented as mean ± SD from three independent experiments. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. f Scattered dot plot of relative levels of IRF6 mRNA in control versus ETS2 -depleted HEKn assessed by qRT-PCR. Expression levels of IRF6 are normalized against ACTB . Data are represented as mean ± SD from three replicates. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. g Model showing binding of ETS2 to the IRF6 −22 kb enhancer, which is favored by the risk allele and which reduces IRF6 expression. Source data are provided as a Source Data file.
    Figure Legend Snippet: a Consensus ETS2 binding motif from the JASPAR database of transcription factor DNA-binding preferences (Matrix ID: MA1484.1) and alignment of the variant site in several mammals. The risk allele (C) is the reference allele but has a lower frequency than the non-risk allele (T) in most populations. The risk allele improves the match to the ETS2 binding site which remains partial. b , c Percent input identified by ChIP-qPCR for anti-ETS2 and anti-H3K27Ac respectively in iOE cells heterozygous for rs661849 using primers specific to the IRF6 −22 kb enhancer site or, as a negative control, to a region 103.7 kb upstream IRF6 transcription start site lacking ATAC-Seq and H3K27Ac ChIP-Seq signals in HIOEC or NHEK. Error bars refer to three ChIP replicates and expressed as mean ± SD. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. NS non-significant. d Sequencing of anti-ETS2 and anti-H3K27Ac ChIP-PCR product of cells heterozygous for rs661849 using the indicated antibody. e Scattered dot plot of relative luciferase activity of the IRF6 −22 kb reporter construct (longest version) harboring the risk allele of rs661849 in control versus ETS2 -depleted primary neonatal keratinocytes (HEKn). Data are represented as mean ± SD from three independent experiments. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. f Scattered dot plot of relative levels of IRF6 mRNA in control versus ETS2 -depleted HEKn assessed by qRT-PCR. Expression levels of IRF6 are normalized against ACTB . Data are represented as mean ± SD from three replicates. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. g Model showing binding of ETS2 to the IRF6 −22 kb enhancer, which is favored by the risk allele and which reduces IRF6 expression. Source data are provided as a Source Data file.

    Techniques Used: Binding Assay, Variant Assay, ChIP-qPCR, Negative Control, ChIP-sequencing, Two Tailed Test, Sequencing, Luciferase, Activity Assay, Construct, Control, Quantitative RT-PCR, Expressing



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    a Consensus <t>ETS2</t> binding motif from the JASPAR database of transcription factor DNA-binding preferences (Matrix ID: MA1484.1) and alignment of the variant site in several mammals. The risk allele (C) is the reference allele but has a lower frequency than the non-risk allele (T) in most populations. The risk allele improves the match to the ETS2 binding site which remains partial. b , c Percent input identified by ChIP-qPCR for anti-ETS2 and anti-H3K27Ac respectively in iOE cells heterozygous for rs661849 using primers specific to the IRF6 −22 kb enhancer site or, as a negative control, to a region 103.7 kb upstream IRF6 transcription start site lacking ATAC-Seq and H3K27Ac ChIP-Seq signals in HIOEC or NHEK. Error bars refer to three ChIP replicates and expressed as mean ± SD. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. NS non-significant. d Sequencing of anti-ETS2 and anti-H3K27Ac ChIP-PCR product of cells heterozygous for rs661849 using the indicated antibody. e Scattered dot plot of relative luciferase activity of the IRF6 −22 kb reporter construct (longest version) harboring the risk allele of rs661849 in control versus ETS2 -depleted primary neonatal keratinocytes (HEKn). Data are represented as mean ± SD from three independent experiments. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. f Scattered dot plot of relative levels of IRF6 mRNA in control versus ETS2 -depleted HEKn assessed by qRT-PCR. Expression levels of IRF6 are normalized against ACTB . Data are represented as mean ± SD from three replicates. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. g Model showing binding of ETS2 to the IRF6 −22 kb enhancer, which is favored by the risk allele and which reduces IRF6 expression. Source data are provided as a Source Data file.
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    a Consensus <t>ETS2</t> binding motif from the JASPAR database of transcription factor DNA-binding preferences (Matrix ID: MA1484.1) and alignment of the variant site in several mammals. The risk allele (C) is the reference allele but has a lower frequency than the non-risk allele (T) in most populations. The risk allele improves the match to the ETS2 binding site which remains partial. b , c Percent input identified by ChIP-qPCR for anti-ETS2 and anti-H3K27Ac respectively in iOE cells heterozygous for rs661849 using primers specific to the IRF6 −22 kb enhancer site or, as a negative control, to a region 103.7 kb upstream IRF6 transcription start site lacking ATAC-Seq and H3K27Ac ChIP-Seq signals in HIOEC or NHEK. Error bars refer to three ChIP replicates and expressed as mean ± SD. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. NS non-significant. d Sequencing of anti-ETS2 and anti-H3K27Ac ChIP-PCR product of cells heterozygous for rs661849 using the indicated antibody. e Scattered dot plot of relative luciferase activity of the IRF6 −22 kb reporter construct (longest version) harboring the risk allele of rs661849 in control versus ETS2 -depleted primary neonatal keratinocytes (HEKn). Data are represented as mean ± SD from three independent experiments. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. f Scattered dot plot of relative levels of IRF6 mRNA in control versus ETS2 -depleted HEKn assessed by qRT-PCR. Expression levels of IRF6 are normalized against ACTB . Data are represented as mean ± SD from three replicates. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. g Model showing binding of ETS2 to the IRF6 −22 kb enhancer, which is favored by the risk allele and which reduces IRF6 expression. Source data are provided as a Source Data file.
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    Image Search Results


    a Consensus ETS2 binding motif from the JASPAR database of transcription factor DNA-binding preferences (Matrix ID: MA1484.1) and alignment of the variant site in several mammals. The risk allele (C) is the reference allele but has a lower frequency than the non-risk allele (T) in most populations. The risk allele improves the match to the ETS2 binding site which remains partial. b , c Percent input identified by ChIP-qPCR for anti-ETS2 and anti-H3K27Ac respectively in iOE cells heterozygous for rs661849 using primers specific to the IRF6 −22 kb enhancer site or, as a negative control, to a region 103.7 kb upstream IRF6 transcription start site lacking ATAC-Seq and H3K27Ac ChIP-Seq signals in HIOEC or NHEK. Error bars refer to three ChIP replicates and expressed as mean ± SD. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. NS non-significant. d Sequencing of anti-ETS2 and anti-H3K27Ac ChIP-PCR product of cells heterozygous for rs661849 using the indicated antibody. e Scattered dot plot of relative luciferase activity of the IRF6 −22 kb reporter construct (longest version) harboring the risk allele of rs661849 in control versus ETS2 -depleted primary neonatal keratinocytes (HEKn). Data are represented as mean ± SD from three independent experiments. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. f Scattered dot plot of relative levels of IRF6 mRNA in control versus ETS2 -depleted HEKn assessed by qRT-PCR. Expression levels of IRF6 are normalized against ACTB . Data are represented as mean ± SD from three replicates. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. g Model showing binding of ETS2 to the IRF6 −22 kb enhancer, which is favored by the risk allele and which reduces IRF6 expression. Source data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: Identification of functional non-coding variants associated with orofacial cleft

    doi: 10.1038/s41467-025-61734-w

    Figure Lengend Snippet: a Consensus ETS2 binding motif from the JASPAR database of transcription factor DNA-binding preferences (Matrix ID: MA1484.1) and alignment of the variant site in several mammals. The risk allele (C) is the reference allele but has a lower frequency than the non-risk allele (T) in most populations. The risk allele improves the match to the ETS2 binding site which remains partial. b , c Percent input identified by ChIP-qPCR for anti-ETS2 and anti-H3K27Ac respectively in iOE cells heterozygous for rs661849 using primers specific to the IRF6 −22 kb enhancer site or, as a negative control, to a region 103.7 kb upstream IRF6 transcription start site lacking ATAC-Seq and H3K27Ac ChIP-Seq signals in HIOEC or NHEK. Error bars refer to three ChIP replicates and expressed as mean ± SD. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. NS non-significant. d Sequencing of anti-ETS2 and anti-H3K27Ac ChIP-PCR product of cells heterozygous for rs661849 using the indicated antibody. e Scattered dot plot of relative luciferase activity of the IRF6 −22 kb reporter construct (longest version) harboring the risk allele of rs661849 in control versus ETS2 -depleted primary neonatal keratinocytes (HEKn). Data are represented as mean ± SD from three independent experiments. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. f Scattered dot plot of relative levels of IRF6 mRNA in control versus ETS2 -depleted HEKn assessed by qRT-PCR. Expression levels of IRF6 are normalized against ACTB . Data are represented as mean ± SD from three replicates. Each dot represents three technical qPCR replicates. Statistical significance ( P value, two-tailed) is determined by Student’s t -test and P value is indicated on the plot. g Model showing binding of ETS2 to the IRF6 −22 kb enhancer, which is favored by the risk allele and which reduces IRF6 expression. Source data are provided as a Source Data file.

    Article Snippet: siRNAs targeting FOXE1 (Santa Cruz, Catalog no. sc-44175) or ETS2 (Santa Cruz, Catalog no. sc-37855) and siRNA controls (Santa Cruz, Catalog no.sc-37007) were transfected into one million HEKn (heterozygous for IRF6 −22 kb SNP) or GMSM-K (homozygous risk for IRF6 -10 kb or −22 kb SNPs).

    Techniques: Binding Assay, Variant Assay, ChIP-qPCR, Negative Control, ChIP-sequencing, Two Tailed Test, Sequencing, Luciferase, Activity Assay, Construct, Control, Quantitative RT-PCR, Expressing